Peginterferon alfa 2a may cause or worsen the following conditions, which may be serious or cause death. Peginterferon alfa2b subcutaneous route description and. Injection, pegylated interferon alfa2b, 10 mcg s0148. Peginterferon alfa2b hiv clinical trials, side effects. If you have any questions about peginterferon alfa 2b sylatron, please talk with the doctor, pharmacist, or other health care provider. Peginterferon is not recommended as monotherapy for any patient group.
Interferons medical clinical policy bulletins aetna. As testing of peginterferon alfa2b continues, additional information on possible side effects will be gathered. The average molecular weight of the pegintron molecule is approximately 31,000 daltons. Two small openlabel trials from europe using combination therapy with peginterferon and ribavirin in children showed comparable efficacy to that seen in adults. Peginterferon alfa 2b injection is used alone or together with ribavirin and another drug called a hepatitic c virus hcv ns34a protease inhibitor such as telaprevir or boceprevir to treat chronic hepatitis c infection. Use peginterferon alfa2b sylatron as ordered by your doctor. Pegintron peginterferon alfa2b injection, 150 mcg per 0. S0145 is a valid 2020 hcpcs code for injection, pegylated interferon alfa2a, 180 mcg per ml or just peg interferon alfa2a180 for short, used in other medical items or. Peginterferon alfa 2b is also approved to treat chronic hepatitis c. Peginterferon alfa2b injection is used alone or together with ribavirin and another drug called a hepatitic c virus hcv ns34a protease inhibitor eg, boceprevir or telaprevir to treat chronic hepatitis c infection. Difference between peginterferon alfa 2a and 2b compare the. Pegylated interferon alfa 2b, sold under the brand name pegintron among others, is a medication used to treat hepatitis c and melanoma. Peginterferon alfa2b or alfa2a with ribavirin for treatment of hepatitis c infection. Randomized study of peginterferonalpha2a plus ribavirin vs peginterferonalpha2b plus ribavirin in chronic hepatitis c.
If you have any questions about peginterferon alfa 2a, please talk with the doctor, pharmacist, or other health care provider. The dose of peginterferon alfa2b may require modification due to development of laboratory abnormalities, such as leukopenia, anemia, or thrombocytopenia. Ropeginterferon alfa2b versus hydroxyurea in patients. As of most of the drugs, peginterferon alfa2a has its set of common side effects.
This use is approved for the sylatron brand of peginterferon alfa 2b. It is used as adjuvant therapy in patients who have had surgery to remove cancer that has spread to the lymph nodes. Peginterferon alfa2b injection is a synthetic manmade version of substances normally produced in the body to fight infection. Peginterferon alfa2b is used in combination with ribavirin or other medications to treat chronic hepatitis c in adults and children who are at least 3 years old. Pharmacokinetics the pharmacokinetics was studied in 32 patients receiving adjuvant therapy for melanoma with sylatron according to the recommended dose and schedule 6 mcgkgweek for 8 doses, followed by 3 mcgkg. Hcpcs code s0148 for injection, pegylated interferon alfa2b, 10 mcg as maintained by cms falls under nonmedicare drug codes. Aidsinfo provides the following drug label solely as an example of the labels available for peginterferon alfa2b. Seer is supported by the surveillance research program srp in ncis division of cancer control and population sciences dccps. Peginterferon alfa 2b sylatron and pegintron is a covalent conjugate of recombinant alfa 2b interferon with monomethoxy polyethylene glycol peg. Peginterferon alfa 2b injection is used alone or together with ribavirin and another drug called a hepatitic c virus hcv ns34a protease inhibitor eg, boceprevir or telaprevir to treat chronic hepatitis c infection. Peginterferon alfa2b drug monograph pediatric care. Peginterferon alfa2b sylatron and pegintron is a covalent conjugate of recombinant alfa2b interferon with monomethoxy polyethylene glycol peg. Oral ribavirin is covered under the pharmacy benefit. Pegylated interferon alfa2a has a larger metabolic clearance than pegylated interferon alfa2b, 57 which has higher renal clearance requiring dose reduction in renal impairment.
Pegasys peginterferon alfa2a is a prescription medication that is. Pegintron tm, peginterferon alfa2b, powder for injection, is a covalent conjugate of recombinant alfa interferon with monomethoxy polyethylene glycol peg. Pegylated interferon alfa2b, sold under the brand name pegintron among others, is a medication used to treat hepatitis c and melanoma. Difference between peginterferon alfa 2a and 2b compare. Peginterferon alfa2b pegintron treatment hepatitis c. Peginterferon alfa2b is used alone or in combination with ribavirin a medication to treat chronic longterm hepatitis c infection swelling of the liver caused by a virus in people who show signs of liver damage and who have not been treated with interferon alpha medication similar to peginterferon alfa2b in the past. Peginterferon alfa2b hcv fda label injection powder. Pegintron peginterferon alfa2b injection, 80 mcg per 0. The specific activity of peginterferon alfa2b is approximately 0. Peginterferon alfa2a side effects, dosage, interactions. Injection, interferon, alfa2b, recombinant, 1 million units. Variations, taking into account individual circumstances, may.
This medicine comes with an extra patient fact sheet called a medication guide. Read it again each time peginterferon alfa 2b sylatron is refilled. Peginterferon alfa2a is used alone or in combination with other medications to treat chronic hepatitis b and chronic hepatitis c, viral infections of the liver. Interferon alfa2b is a watersoluble protein with a molecular weight of 19,271 daltons produced by recombinant dna techniques. The sylatron brand of peginterferon alfa2b is used only in adults, to treat melanoma skin cancer after surgery. Apr 09, 2020 the biological activity of pegintron is derived from its interferon alfa 2b moiety. A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene glycol peg, used as an antiviral and antineoplastic agent.
All of the following must be met as a conditions for coverage. Peginterferon alfa2b an overview sciencedirect topics. The molecular weight of the peg portion of the molecule is 12,000 daltons. Peginterferon alfa2a can cause lifethreatening infections, autoimmune disorders, serious mood or behavior problems, or a stroke. A randomised trial to compare the pharmacokinetic, pharmacodynamic, and antiviral effects of peginterferon alfa2b and peginterferon alfa2a in patients with chronic hepatitis c compare j hepatol. Peginterferon alfa2b side effects, dosage, interactions. Nov 09, 2018 peginterferon alfa 2b may cause serious or fatal side effects, and can worsen a medical condition you already have. Read it again each time peginterferon alfa 2a is refilled. Call your doctor if you have symptoms such as mood or behavior changes, chest. After a first course failed, a second course of antiviral therapy achieved normalization of serum aminotransferases and hepatitis c viral rna, but also. Peginterferon alfa 2b injection is a synthetic manmade version of substances normally produced in the body to fight infection. The recommendations in this online publication do not indicate an exclusive course of treatment or serve as a standard of medical care. S0148 hcpcs code peg interferon alfa2b10 hcpcs registry.
In a patient with chronic hepatitis c, peginterferon alfa2b was associated with interstitial pneumonia, which was exacerbated by ursodeoxycholic acid 35 a. Interferon alfa2b is a protein produced by recombinant dna techniques. Peginterferon alfa2b and weightbased or flatdose ribavirin in chronic hepatitis c patients. Also, this drug is approved worldwide for the treatment of chronic hepatitis c which includes immunocompromised individuals with hiv and cirrhosis as a coinfection. The sylatron brand of this medicine is used only in adults, to treat melanoma skin cancer after surgery. If you have any questions about peginterferon alfa2a, please talk with the doctor, pharmacist, or other health care provider. Srp provides national leadership in the science of cancer surveillance as well as analytical tools and methodological expertise in collecting, analyzing, interpreting, and disseminating reliable populationbased statistics. He described the current optimal therapy for hcv 1 infection as peginterferon alfa 2a 180 mcg weekly or peginterferon alfa 2b 1. In the united states, peginterferon alfa2a was approved for medical use in the year of 2002 by the world health organization. Interferons can upregulate cell surface expression of class ii histocompatibility antigens, which increases the potential for transplant rejection.
Peginterferon alfa2b pegintron treatment hepatitis c online. Ropeginterferon alfa2b versus hydroxyurea in patients with. Peginterferon alfa2b is also approved to treat chronic hepatitis c. Jan 06, 2020 this medicine comes with an extra patient fact sheet called a medication guide. Pronunciation peg in ter feer on al fa too bee brand names. Peginterferon alfa 2b and weightbased or flatdose ribavirin in chronic hepatitis c patients. Signal transduction is initially mediated by the jakstat activation, which may occur in a wide variety of cells.
They may include headache, feeling tired, mood changes. This code description may also have includes, excludes, notes, guidelines, examples and other information. In the field of pharmaceuticals, different drugs are developed for different disease conditions. Injection, interferon, alfa 2b, recombinant, 1 million units.
Miyase s, haraoka k, ouchida y, morishita y, fujiyama s. Drugs administered other than oral method, chemotherapy drugs j92 is a valid 2020 hcpcs code for injection, interferon, alfa2a, recombinant, 3 million units or just interferon alfa2a inj for short, used in immunosuppressive drugs j92 has been in effect since 01012019. S0145 injection, pegylated interferon alfa2a, 180 mcg per ml the above description is abbreviated. Peginterferon alfa2b may cause serious or fatal side effects, and can worsen a medical condition you already have. Aug 01, 2017 treatment with ropeginterferon alfa 2b, a monopegylated proline interferon, reduced jak2 allele burden in patients with polycythemia vera pv and appeared to modify the underlying disease, according to an analysis of the randomized, controlled, phase iii proudpv study. Pediatric patients treated with peginfalfa2a plus ribavirin showed a delay in weight and height increases. Six participants who were taking peginterferon alfa 2b withdrew from the study before week 48. Peginterferon alfa2b definition of peginterferon alfa2b. The dose of peginterferon alfa 2b may require modification due to development of laboratory abnormalities, such as leukopenia, anemia, or thrombocytopenia. Persistently elevated lfts six months positive hcv rna titer.
Peginterferon alfa2b injection is used alone or together with ribavirin and another drug called a hepatitic c virus hcv ns34a protease inhibitor such as telaprevir or boceprevir to treat chronic hepatitis c infection. Inclusion or absence of a drug label on the aidsinfo site does not imply endorsement or lack thereof by aidsinfo. Interferons are proteins released in the body in response to viral infections. If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot. Russ, in comprehensive clinical nephrology fourth edition, 2010. It is given by injection under the skin side effects are common. Ribavirin po 1200 mgday based on body weight plus sofosbuvir 400 mg po qday. Upon binding, the receptor subunits dimerize, and activate multiple intracellular signal transduction pathways. They are developed through researchbased evidence which causes the drug to be very effective on the particular disease condition with fewer side effects. Unlike hydroxyurea hu, a standard treatment for pv, ropeginterferon specifically targets jak2 mutant.
Rumi mg, aghemo a, prati gm, dambrosio r, donato mf, soffredini r, del ninno e, russo a, colombo m. S0145 injection, pegylated interferon alfa2a, 180 mcg per ml. Pegintron peginterferon alfa 2b injection, 80 mcg per 0. Pegylated interferon an overview sciencedirect topics. As testing of peginterferon alfa 2b continues, additional information on possible side effects will be gathered. Treatment with ropeginterferon alfa2b, a monopegylated proline interferon, reduced jak2 allele burden in patients with polycythemia vera pv and appeared to modify the underlying disease, according to an analysis of the randomized, controlled, phase iii proudpv study.
Nov 09, 2018 peginterferon alfa 2a can cause lifethreatening infections, autoimmune disorders, serious mood or behavior problems, or a stroke. Sylatron peginterferon alfa 2b prior auth criteria proprietary information. Peginterferon alfa 2b binds to and activates the human type 1 interferon receptor. J9214 hcpcs code interferon alfa2b inj hcpcs registry. Pegintron, peginterferon alfa2b powder for injection, either alone or in combination with ribavirin rebetol, is an alternative to standard interferon alfa plus ribavirin for treatment of chronic hepatitis c. J9214 is a valid 2020 hcpcs code for injection, interferon, alfa2b, recombinant, 1 million units or just interferon alfa2b inj for short, used in immunosuppressive drugs. Call your doctor if you have symptoms such as mood or. Peginterferon alfa2b binds to and activates the human type 1 interferon receptor. Pegintron, peginterferon alfa 2b, is indicated for use alone or in combination with rebetol ribavirin, usp for the treatment of chronic hepatitis c in patients with compensated liver disease who have not been previously treated with interferon alpha and are at least 18 years of age. It is given as a shot into the fatty part of the skin. Read it again each time peginterferon alfa2a is refilled. Pegylated interferon alfa 2a has a larger metabolic clearance than pegylated interferon alfa 2b, 57 which has higher renal clearance requiring dose reduction in renal impairment. Peginterferon alfa2b definition of peginterferon alfa. Six participants who were taking peginterferon alfa2b withdrew from the study before week 48.
Fda approved indications pegasys is indicated for the treatment of. Peginterferon alfa2b may cause or worsen the following conditions that may be serious or cause death. Chronic hepatitis c chc as part of a combination regimen with other hepatitis c virus. J92 is a valid 2020 hcpcs code for injection, interferon, alfa2a, recombinant, 3 million units or just interferon alfa2a inj for short, used in immunosuppressive drugs. Comparison of peginterferon alfa2a and alfa2b for treatment. Interferons are important for fighting viruses in the body, for regulating reproduction of cells, and for regulating the immune system.
This use is approved for the sylatron brand of peginterferon alfa2b. Peginterferon alfa2b by injection national library of. Pubmed abstract mangia a, santoro r, minerva n, et al. Several fdaapproved drug labels may be available for peginterferon alfa2b. Restricted access do not disseminate or copy without approval. It is obtained from the bacterial fermentation of a. Nov 15, 2017 key difference peginterferon alfa 2a vs 2b. Peginterferon alfa 2b may cause or worsen the following conditions that may be serious or cause death. Pediatric patients treated with peginf alfa 2a plus ribavirin showed a delay in weight and height increases. S0145 is a valid 2020 hcpcs code for injection, pegylated interferon alfa2a, 180 mcg per ml or just peg interferon alfa2a180 for short, used in other medical items or services. Peginterferon alpha2b definition of peginterferon alpha. Interferons can upregulate cell surface expression of class ii histocompatibility antigens, which. Peginterferon pegintron, schering corporation, kenilworth, nj is a new formulation of interferon recently approved for the treatment of hcv. Interferon alfa 2b is a protein produced by recombinant dna techniques.
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